The design of strategy for animal cell flow-rate culture control usually includes three factors: control standards (the maintenance of different nutrients), flow-rate method (continuous or intermittent) and control strategy. Like microbial systems, the control of animal cell culture flow-rate can be divided into open-loop and closed-loop. In open-loop, culture is based on optimal flow-rate routes, such as the mathematical model of optimal control theory, so it is important to model the kinetics of cell growth and product generation.

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